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What Is SOX2 Antibody?

SOX2 is an intron-free gene that encodes an SRY HMG-box (SOX) group of transcriptional factors that are involved in the regulation of embryonic growth and in the determination of the fate of cells. This product from the SOX2 gene is essential for the maintenance of stem cells throughout the central nervous system and also regulates the expression of genes within the stomach. 

The SOX2 gene is located within an intron of a different gene known as the SOX2 overlap transcript (SOX2OT). Additionally, SOX2 antibody-protein may act as a transcriptional activator following making a protein that is in a complex that is a part of other proteins. Variations of SOX2 gene mutations SOX2 gene has been linked with bilateral anophthalmia.

This is the most severe type of structural eye malformations, optic nerve hypoplasia, and microphthalmia syndrome. Embryonic stem cells (ESC) are derived from the cell wall of the blastocyst and are distinct in their pluripotency and the potential to self-renew. 

Research has shown that a group of transcription factors including Oct-4 Sox2, Oct-4, and Nanog is a transcriptional network that keeps the cells at a pluripotent condition. Chromatin immunoprecipitation tests demonstrate the fact that Sox2 and Oct-4 interact with thousands of genes' regulatory sites that regulate pluripotency of cells and the development of embryos in the early stages.

Silencer knockdown of either Sox2 or Oct-4 causes the loss of pluripotency. The overexpression inducible of Oct-4 and Sox2 in combination with the additional genes that regulate transcription, such as Klf4 and cMyc, could change the human and mouse somatic cells into pluripotent status.